Laboratory confirmation of infection but with no clinically compatible manifestations [1]:
- Isolation of rubella virus from an appropriate clinical specimen; OR
- Detection of rubella virus RNA; OR
- Positive serologic test for rubella IgM antibody in the absence of recent immunization with rubella-containing vaccine; OR
- Rubella IgG persisting for longer than would be expected (approximately 6 months after birth) from passive transfer of maternal antibody, or in the absence of recent immunization.
1. Definition of clinically compatible manifestations
- Cataracts or congenital glaucoma (either one or both count as one)
- Congenital heart defect
- Sensorineural hearing loss
- Pigmentary retinopathy
- Purpura
- Hepatosplenomegaly
- Microcephaly
- Micro opthalmia
- Mental retardation
- Meningoencephalitis
- Radiolucent bone disease
- Developmental or late onset conditions such as diabetes and progressive panencephalitis and any other conditions possibly caused by rubella virus.
