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Hantavirus

Case Definition

Confirmed Case

Clinical illness with laboratory confirmation of infection:

detection of IgM antibodies to Hantavirus
detection of a significant (e.g. fourfold or greater) increase in hantavirus-specific IgG antibody titres
detection of hantavirus-specific RNA in an appropriate clinical specimen
detection of hantavirus antigen by immunohistochemistry

Probable Case

Clinical illness in a person who is epidemiologically linked to a confirmed case

Definition of clinical illness

Febrile illness (Temperature > 38.3° C [101° F] oral) requiring supplemental oxygen

AND

bilateral diffuse infiltrates (may resemble acute respiratory distress syndrome [ARDS])

AND

develops within 72 hours of hospitalization in a previously healthy person

OR

unexplained illness resulting in death plus an autopsy examination demonstrating non-cardiogenic pulmonary edema without an identifiable specific cause of death